CONTROLLED-RELEASE PREDNISOLONE POLY (DL-LACTIDE) MICROSPHERES: IMPACT OF FORMULATION PARAMETERS, CHARACTERIZATION AND RELEASE MECHANISM

Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system.

Successful vaccine application means maximum protection with minimal number of administrations. A rational development of vaccines involves studies of the nature of the antigen as well as of the adjuvant to be used to improve the immune responses. This has provided the impetus for studies to design the degradable devices and for different approaches to antigen delivery by different routes of ad...

formulation and characterization of ionotropic cross-linked chitosan microspheres for controlled release of ascorbic acid

Parameters influencing the antigen release from spray-dried poly(DL-lactide) microparticles.

Microparticles were produced by spray-drying from a high molecular weight polylactide (PLA R207) for the development of long-lasting controlled release systems of vaccines, which may be designed to obviate the need for booster doses. The current investigation considered the effect of both technological parameters (inlet air temperature and spray rate of feed) and polymeric solutions (polymer co...

preparation and characterization of tri-block poly(lactide)- poly(ethylene glycol)- poly (lactide) nanoparticles for sustained release of rivastigmine

Poly(lactide-co-glycolide) microparticles as systems for controlled release of proteins -- preparation and characterization.

Poly(DL-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) copolymers were prepared by bulk ring opening polymerization of lactide and glycolide and characterized by GPC, FTIR, 1H NMR and DSC. Copolymers with different molar masses at a constant lactide/glycolide ratio were used for preparation of bovine serum albumin (BSA)-loaded microparticles by the double emulsion w/o/w...